The International Union of Pure and Applied Physics will turn 100 years old in 2022. A series of activities will be carried out to celebrate this Centenary. The Centennial Symposium will take place at ICTP, Trieste, on 11, 12 and 13 July 2022 (a live connection with the ICHEP plenary session is foreseen on the morning of July the 11th). We hope that many people will be able to participate in person, but we understand that some participants will be on Zoom and so the meeting will be fully hybrid. The Symposium will include plenary talks by keynote speakers and other activities, with an emphasis on aspects of the IUPAP history, on developing countries, collaborations among countries, physics education, and many other items consistent with the IUPAP mission. Then, sometime in 2023, the year that marks the 100th anniversary of the First IUPAP General Assembly, we hope to be able to organise a General Assembly at the Science Gateway of the European Organization for Nuclear Research (CERN), a new scientific education and outreach center that is expected to be finished in 2023.The IUPAP is deeply committed to contribute towards the application of physics and other scientific disciplines to solve the problems of concern to humanity. The Union is firmly in favor of taking actions that will help achieve sustainable development and a more balanced and inclusive world. To advance in this respect, IUPAP is leading fellow scientific unions and other partners to promote and organize an International Year for Basic Sciences for Sustainable Development (IYBSSD) in 2022/2023. IYBSSD activities will be combined with the IUPAP’s centennial celebration to have a greater impact.